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Presentation of Professor Doctor Christian Daniel Assoun 
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          Original Silica – G5

LEGAL AND HISTORIC INFORMATION ON THE SILANOLS

 

Organo-silanes, more known under the generic name of silanols, started becoming known shortly after the Second World War and other organic silicon complexes have been studied since 1954. Several patents PCT have been developed in Europe and in the USA over the last 50 years or more. One can consult the European or US Patent and Trademark Offices, to obtain documentation on the subject.  

Silicon represents approximately seven grams per pound in the living organism and is also one of the principal components of the earth’s crust of which it represents nearly 28%. Back in the Seventies, a French researcher, Norbert Duffaut, developed what one can regard as one of the first molecules being able to subscribe to the name of Organic Silicon. (In bibliographical references since 1954, a hundred molecules associating Silicon and organic compounds of aliphatic or aromatic chains were worked out by the chemical, cosmetic and pharmaceutical industry).  

After years of tests as private customers, NR. Duffaut was joined by another French researcher, Dr. in sedimentology, Loïc Le Ribault. Together, they developed the G4 molecule. After the death of Norbert Duffaut, Loïc Ribault worked out the llrG5, as the various deposits of marks and patents attest, some of which are now in the public domain (duration of patent 20 years). Let us announce the treatments containing Organic Silicium of Doctor G. Rager, cardiologist who collaborated with Doctor R. Saubens in Bordeaux. In addition, let us note the deserving work of Dr. Voisin, a pharmacist.

Many laboratories continued research on the improvement of Organic Silicon, and today, there exist more than ten forms of Silanols of which Original Silica G5 ™, (Si-G5 ™) of Glycan Group which was developed by Prof Dr. Christian Daniel ASSOUN, biophysicist whose companies are specialized in the mineral and nutritional complements since 1984.

The patents of Dr. Assoun for the development of the primary products of Silanols were deposited in 1975 in France, in 1976 in England and 1994 in Switzerland. The scientific activities in research and the development of Silanols of Dr. ASSOUN are definitely more recent than certain commercial developments of the Organic Silicon which one finds on the market as well as on the Internet today.   

During the years, many therapeutic claims were allotted to Silanols, some are very whimsical and untrue. In any event, these claims must be confirmed by Bibliographical Studies, Toxico-Pharmacology and finally Clinical Studies. The Agencies of the drugs in Europe and in the USA (FDA) appreciably apply the same criteria to allot to a product a confirmed and determined therapeutic virtue. Consequently, Silanols cannot (except by legal therapeutic demonstration) be presented or considered drugs, but they are nutritional suppliments or at best the neutraceutiques ones.  

The presentation of Silanols as systemic therapeutic agents of one or several pathologies, is not legal, unless a complete study would prove this. Generally, the public is neither a pharmacist, neither doctor, nor biologist and cannot judge erroneous claims, and thus it is appropriate in the name of medical and commercial ethics to clarify the legal, nutritional and neutraceutic position of Silanols. In the pages which follow we will present Silicon and the various molecules that one can in general use to describe the various applications of the Organic Silicon and of Glycan’s Original Silica G5 in particular, by taking care to state only the applications having been checked against rigorous scientific techniques.   

BIODISPONIBIBILITY OF THE VARIOUS MOLECULES  

In order to better understand the biodisponibility of Organic Silicon, it is important to understand the difference between the various biochemical shapes of silica (SiO2), of the Silicium element (Si) and different the Silanols.  

Silicon is the most widely found metalloid on the planet as it represents 28% of the earth’s crust.  

It was thought to be a trace element for many years but research during the last twenty years has shown that it is in fact a secondary macro-element. Here’s a quick reminder of these major elements:  

Macro-elements: Sodium (Na), Potassium (K), Phosphorous (P), Calcium (Ca), Magnesium(Mg)   

Secondary macro-elements: Silicon (Si), Boron (B), Bromine (Br), Rubidium(Rb), Strontium (Sr)   The amount of silicon in the body is about 7 grams, almost twice the amount of iron which shows its importance at a biological and structural level.  

It is found virtually everywhere including in the blood (about 10 mg /liter equal to one tenth of the calcium level) and the organs and tissues: bone, blood vessel walls, spleen, tendons, muscles, liver, pancreas, kidneys, heart, endocrine system, eyes, skin… it is also present in the heart of the smallest biological cell because it contains three centrioles made of silicon.

The very high levels of silicon in the fetus reduces with age to such an extent that extracellular levels can be reduced by as much as 80 % in elderly people.  

Silicon is poorly available in its non-soluble form (colloidal) but at about 10 % a nonspecialized protein actively transports it. Furthermore, even in its organic form, i.e. the atypical acid Si(OH)4 is changed by replacing one hydroxyl (OH) combination with at least one hydrocarbon (CH) combination, silicon is a very unstable metalloid that is quickly polymerized and this has also limited the concentration of elemental silicon in organic silicons to a maximum of 1 gram. On the other hand, the body can use over 65 % of organic silicon.  

The daily requirement to maintain the silicon level in the body at the right level are quite high because it requires a daily intake of 15 – 25 mg of elemental silicon per day for maintenance and up to 40 mg in compensation (collagen restructuring). Most organic silicons contain about 500 mg of elemental silicon and sometimes much less. What this means is that to satisfy the daily requirements mentioned above, you need to consume about 1 liter of Silanol per week.  

Professor ASSOUN and his research teams are aware of this problem and have looked at ways both for stopping the polymerization and for increasing availability. This work has led to the birth of Original Silica G5.     

PHYSIO-CHEMICAL PROPERTIES OF SILICON  

Silicon (Si) is a metalloid – a metal crystal with reverse optoquantum properties, when means that when it is irradiated by UV radiation, it produces an electric current and, under very specific electrical conditions, it can emit a quantifiable radiation – which as we have seen makes up almost 28 % of the earth’s crust (27.7) and this makes it the fourth most abundant element behind hydrogen, nitrogen and oxygen and the second component of the earth’s crust behind oxygen. The Swede, Jöns Jacob Berzelius, discovered it in 1824.  

In its amorphous form, it is a brown powder; in its crystalline form it is a metallic gray. As a solid, it does not react with oxygen, water or most acids. Silicon dioxide dust (SiO2) is slightly toxic and very irritant. It is 14th in the periodic table and its atomic number is 14 and its valence can be 2 and/or 4. Its atomic weight is 28.0855 amu. Its melting point is1,410°C, its boiling point is almost the double at 2,680°C and its critical temperature is 4,920°C. Its density is 2.32 g/cm3.  

The etymology of its name is based on the Latin word silicis meaning flint (which is in fact an impure form of quartz).  

It is the main element in clay, granite, quartz and sand. To produce silicon commercially, silicon dioxide (SiO2) is reacted with carbon at 2,000° C. It is used for glass production in the most common form as the dioxide SiO2. Silicon carbide is one of the hardest substances known to man and is used in some polishes. It is used in semi-conductors in its monocrystaline form.  

The mineral form

It is most widespread as the dioxide. In its purest form, the dioxide forms quartz. In this form, the silicon dioxide forms strong bonds with oxygen called covalent bonds where each silicon atom is linked to two oxygen atoms hence the name dioxide for this substance.   

The second solid form in which silicon is found is as silicates. Silicates are the main components of rocks and semi-precious or fine stones.  

Silicon oxide is used in the semi-conductor, sand paper and abrasives, glass and cement industries. It is also used as a thermal insulation (refractory furnaces, car spark plugs, etc.)

The liquid form

The natural liquid form of silicon is ortho-silicic acid, an atypical acid Si(OH)4. This is the form that is present in plants where their chemical processes produce organo-silicates that are

used by the plant. However, most of the silicon is oxidized and so only a very small proportion is biologically available.  

The Colloidal Organic Silicon

To be called colloidal organic silicon, as we have seen, the silicon must contain one or more hydrocarbon groups and these are also called silanes and usually have the following form: CHx Si(OH)3. .  

A colloid is to some extent halfway between a solid salt and a soluble salt; that means it is more assimilable/available than a solid salt but much less than a liquid one. To increase the assimilation of a colloid, the only possible technique is to reduce the size of the molecules in suspension and this process is what has been performed by The Glycan Group with Original Silica G5 and Arthrosil Si-G5.  

It is in this form that it has greatest bioavailability for the body and the hydrocarbon group and the hydroxyl radicals (OH) are both necessary for this.  

But let us come back to colloidal silicon: to pass the digestive barrier, Silicon joins a protein which will be used as a carrier. But this protein is not specific to Silicon and will also retain other trace elements, minerals and other substances. It has, consequently, a threshold of saturation which limits the quantity of the assimilable Silicon. If it was necessary to indicate a figure concerning its rate of assimilation, this rate would be around 7% at the most.    

The Original Silica G5 ™ (Si-G5 TM)  

Organic Silicon is obtained from the “pre-digestion”, i.e. transformation, of mineral Silicon through the action of micro-organisms on quartz crystals (rock crystal). Among the factors developing the activity of these micro-organisms there are certain amino acids (components of the proteins) which join with Organic Silicon to help it become water-soluble. This will result in a solution that we can classify in the family of the Amino-Silanols of acids.

From its hydro solubility and because of its direct connection with the conveying amino acids, Original Silica G5 is almost directly absorbable at very high rates. If we want to give a figure, the rate lies between 60% and 70% which is extremely high. Si-G5 does not result from the action of the micro-organisms.  

The acido-soluble organic derivatives take part in the metabolic exchanges. They represent a form which is ideally absorbed through the digestive tract. We know that they can, in addition, cross the skin barriers and thus be absorbed by simple cutaneous application.

USE, SOURCES AND UTILITY of Organic Silicon

Silicon and plants

There are certainly multiple sources of Silicon in our nutrition and especially in grasses but it is much less present in calcium providing plants or pulses. However, the form in which Silicon is present in plants is not readily bioavailable to the body. The plants, such as bamboos and cereals can accumulate up to 10 % of Silicon. The Silicon accumulated in the plants comes primarily from water out of the grounds. The accumulation of Silicon in the plants thus is mainly controlled by the solubility and the kinetics of dissolution of minerals or biological activity in the ground.  

Recent experimental work (ref. ARVALIS) showed that the phytolithes of soils constitute the source of Silicon which is the most easily available for the plants.   

Nevertheless, even if ingesting plants with very high Silicon content, our organism can assimilate only 3% of the 10% content in the plants.   

Silicon and human biology

With more than 7 g in our bodies, Silicon is one of the top 10 natural elements found in our bodies. Various studies over the last twenty years have shown the importance of Silicon in human biochemistry.  

Its action on the pure physiological level is of importance, but one too often neglects his opto-quantum action (work of Dr. Christian Daniel Assoun in Quantum Medicine), i.e. its action on the level of the exchanges within the intra and extra cellular substances. In addition, we are with respect to this confronted with the problem of daily contribution, from 15 to 45 mg, even more in certain cases, which requires a certain concentration and a maximum assimilation.  

The normal daily requirement is estimated at 40 mg of elemental silicon. Ingesting 30 ml of Original Silica G5 provides about 40 mg of elemental Silicon and thereby covers this need. Under optimal conditions, Silicon will promote better health. However, it is not the miracle treatment that some manufacturers would like us to believe. Organic Silicon is a nutritional supplement that is very useful.

It is an essential nutritional complement, necessary to the micro-nutrition of our organism. In addition, Silicon allows a potentialization of the absorption of major macro-nutrients such as Magnesium (Mg) and Calcium (Ca).   

It appears also that he different Organic Silicon forms have anti-microbic properties. In recent researches it appears also that Silicon could take part in the protein synthesis and the protection of the polymerases and telomeres. Its direct or indirect implication in our immunity is also the subject of active research at the present time.  

ORIGINAL SILICA G5, OSSIFICATION AND JOINTS  

Bone and bony tissue have an abundant matrix that encloses sparsely distributed cells. This matrix is made up of about 25 % water, 25 % fibers – mainly collagen) and 50 % mineral salts (Ca). When the salts are deposited on the collagen fibers in the matrix, crystallization occurs and the bony tissue hardens; this process is called calcification or mineralization. Bone’s hardness is due to this crystallization and its suppleness to the presence of collagen fibers. The latter provide more malleability, in other words they make bone less brittle, e.g. an eggshell or oyster shell does not contain these fibers and is much more brittle. Calcification cannot occur unless this collagen is present. Different work has shown the undeniable role of silicon in collagen fiber synthesis where it is also associated with vitamin C.  

Furthermore, we know that high concentrations of silicon are always found in areas of high calcification: e.g. the extremities of bones that are growing. Its concentration in these sites varies depending on the mineralization and increases at the same time as it increases. When mineralization of a site is complete the level of silicon is at its lowest. Silicon therefore appears to be an essential element for bony growth and its deficiency may be a limiting factor, e.g: a chick with a silicon deficiency has skull abnormalities associated with a significant fall in bone’s collagen content and abnormalities in long bones and connective tissue.  

In cases of bone disease, supplementing with Original Silica G5 produces excellent results both in terms of the pain reaction and remineralization of the bone. Silicon and calcium work closely together and calcification of fractures can be greatly accelerated by organic silicon supplements.  

Because of its role in bone mineralization and growth, Original Silica G5 is an excellent remedy for osteoporosis. Trials conducted on different types of osteoporosis – senile, cortisone induced and post-menopausal – have shown very good results, especially for post-menopausal osteoporosis where biological testing of the bony tissues showed a large increase in recalcification.  

Ageing produces two important skeletal effects: demineralization and a reduction in collagen. The mineral loss starts in women at about 30 year of age and increases between 40 and 45 years old when oestrogens diminish. This process continues with age. In men, the demineralization starts at about 60 years old. The reduction in collagen results in rigid bones, which makes them more susceptible to shocks. Preventive measures can be taken:  

Physical exercise: mechanical stress strengthens bony tissue.  

Nutritional hygiene ensuring an adequate supply of minerals: Calcium, Phosphorous, Magnesium, Manganese, etc.  

Vitamins: A, C, B6 and B12, D, etc.  

Exposure to light and an external supply of Silicon after a certain age to induce collagen fiber production and promote calcification.

Let’s not forget that bony tissue is the body’s main calcium reserve and that its concentration in the blood is carefully regulated with the bones playing the role of a buffer zone and liberating or absorbing calcium which is an indispensable co-factor in many metabolic processes.  

In addition, the Organic Silicon G5 is also known to play an active part in the good health of teeth, gums, hair and nails.  

ORIGINAL SILICA G5 AND JOINTS

There are three types of joint: fibrous, cartilaginous and synovial. Their common feature is the presence of connective tissue that contains elastin or collagen. We know of the essential role played by Silicon in the synthesis of these two fibers.  

Joints must be flexible to allow movement and resist tension. The can degenerate or age prematurely which results in wear and irritation as in arthrosis. Effected joints are usually those that carry the body’s weight: spine, hips, knees, feet and some joints in the hand.  

Arthrosis appears in general at about 45 to 50 years old and its frequency will increase with age if nothing is done. They occur more frequently in women. Arthrosis involves a deterioration of the articular cartilage which has a role similar to a sponge that absorbs shocks. When this disappears, the bones can touch each other and this leads to pain and wear.  

Original Silica G5 / Arthrosil G5 (Silicon enriched with Glucosamine and Chondroitin sulfate) is even able to act in the pain process and cartilage regeneration. Its rapid action on the pain is the first to be perceived. Cartilage regeneration then follows. The greater the decline in our silicon levels the more spectacular the results in terms of pain: rheumatism of the knee, the back or the fingers are soothed in a few days or a few weeks. These results are usually long-lasting: it involves a reconstruction.  

In respect of arthritis, which is an inflammation where cartilaginous and osseous lesions follow synovial lesions, with swelling, occasional redness and heat in the joint, there can be a tenfold clinical improvement. Once again Original Silica G5 is acting on both, the pain and the inflammatory processes.

For rheumatoid poly-arthritis, an autoimmune condition where the body attacks its cartilages and joint surfaces leading to inflammation, pain and loss of joint function, it is important to treat the condition as soon as possible to avoid fibrous tissue replacing the synovial membrane and blocking the joint. This synovial membrane contains elastin which gives it is flexibility.  

Original Silica G5 acts on the elastin production as well as the inflammatory process. Rheumatoid poly-arthritis effects 1 % of the population and three out of four people affected are women.    

ORIGINAL SILICA G5, CARDIOVASCULAR FUNCTION AND CIRCULATION  

Silicon is an integral part of blood vessel walls: its presence is essential for synthesizing elastin and collagen fibers. It therefore helps conserve the elasticity of blood vessels. This property and it contractibility are two important characteristics for the proper function of the blood circulation. Silicon must also be present for vascular tone.  

There is a relationship between the concentrations of silicon in the aorta tissue – the aorta is very rich in elastin and collagen fibers – and arteriosclerosis (hardening of arteries causing hypertension). Arteries subject to arteriosclerosis have a silicon level that is much lower than healthy arteries. Ingesting Original Silica G5 helps conserve the integrity of vascular elastin fibers and reduces the permeability of arterial walls; it increases the intra-cellular cement and the thickness of elastin fibers; it also maintains a high level of hyrdolase, the enzyme That can change cholesterol esters into free cholesterol. Lipid infiltration within the vascular system are inversely proportional to the silicon levels.  

In people with weak venous valves, blood tends to collect under the influence of gravity; this results in an overloading of veins and their walls start to distend. Over time, this wall loses its elasticity, stretches and becomes flaccid. The valve failure leads to a dilated and tortuous vein known as a varicose vein.  

Because of its excellent bio-availability, Original Silica G5 acts effectively on vascular tone and on the good function of these vessels. It provides the vessels with flexibility and thereby has an indirect effect on blood pressure. Better circulation leads to warming of the skin. Organic Silicon G5 in conjunction with vitamin E is also very useful for eliminating swollen vessels. Blood also carries hormones and their action will be enhanced if the circulation works properly.

Within the cardiac system, connective tissue envelops and separates. It is found in the epicardium that makes up the external layer of the heart. The endocardium that lines the inside of the myocardium lies on a fine layer of connective tissue. It is also connective tissue that divides the myocardium into distinct auricular and ventricular muscle masses. The fibrous connective tissue rings and sheets act as electrical insulation between the auricles and ventricles.  

The heart also has valves that stoop backflows of blood. These valves consist of dense connective tissue covered in myocardium. The valves open and close in reaction to pressure changes caused by the cardiac muscle’s contractions and relaxations. Most heart problems are related to the coronary artery circulation inefficiencies caused by blood clots or the fatty arteriosclerosis deposits. The presence of silicon, which is a connective tissue component, is the best insurance for maintaining the integrity of cardiac surfaces.  

ORIGINAL SILICA G5, MUSCLES AND TENDONS  

There are three types of muscle tissue: striated, cardiac and smooth. In this section we are going to look at striated muscle tissue, which is mainly attached to bones but can also be attached to the skin and deep fascia’s. This muscle tissue is surrounded and protected by fascia, which is a large band of protective fibrous connective tissue. This fascia, called deep, keeps muscles together and separates them into functional groups. It allows the muscles to move freely, transports nerves and vessels and, above all, it fills the spaces between muscles.  

Three layers of connective tissue (epimysiumn perimysium and endomysium) extend from the deep fascia to protect and strengthen the muscle; the first envelope protects the muscle, the second protects the fascia of 10 to 100 muscle fibers and the third penetrates to the interior of each fascia and separates each muscle fiber. These three layers extend and provide the collagen fiber for the connective tissue that connects the muscle to the bone. When they extend beyond the muscle, they become a tendon. When striated muscle contracts, it pulls on the tendons and its connective tissue envelops. These are stretched then contract and pull the bone to which they are attached causing it to move.  

We have already seen the role of Original Silica G5 in connective tissue and on its collagen fibers. In this case it provides flexibility and mobility to muscles and tendons. It also helps eliminate pain.  

Another fascia called superficial fascia is found between the skin and the deep fascia of the muscles; it is called the sub-cutaneous layer. It consists of loose connective tissue and has several functions; it stores water and fat, forms an insulating layer that prevents loss of body heat (don’t forget that muscle contractions generate up to 85 % of body heat), protects the body from external shocks and allows blood vessels and nerves to enter and leave muscles.  

Through its percutaneous action, Original Silica G5 helps strengthen some of the superficial fascia’s functions. It provides better protection against the impact of climatic damage: humidity, cold, rain, and pressure changes. Silicon provokes an increase in the number of red blood cells, which indirectly results in better oxygen transportation, and muscles consume large amounts of oxygen when working. It can therefore produce better performances.

ORIGINAL SILICA G5 AND INTERVERTEBRAL DISCS  

Intervertebral discs act as shock absorbers: they are constantly being subjected to compression. Each disc is made of an external ring of fibro-cartilage – called the anulus fibrosus – and a soft internal structure that is pulpy and very elastic, the nucleus pulposus. The discs form good joints that allow a range of movements for the spine. Their role is also to absorb vertical shocks by being compressed: they become flattened, enlarge and spread out in their intervertebral spaces.

It is known that the cartilaginous tissue contains up to 100 mg / kg of silicon in fresh tissue. The body’ silicon content reduces as we discussed earlier due to its poor bioavailability for man. However we need silicon to renew our cartilage. It ensures the integrity of our cartilaginous tissues, nourishes them and stimulates collagen production. The fibro-cartilage is rich in networks of collagen fibers whilst the nucleus consists of elastin fibers. Original Silica G5 through its high bioavailability acts effectively on the regeneration of intervertebral discs.  

ORIGINAL SILICA G5 AND SKIN  

We are not telling anyone anything original when we say that the skin owes its flexibility to the presence of special collagen fibers that are poorly renewed as we get older, which results in a slackening of the cutaneous tissue, wrinkles, etc.  

Using exogenous collagen has several drawbacks, firstly the cost and the very poor rate of collagen recuperation by the body. Furthermore, using exogenous collagen can have an asphyxiating effect on the skin and can stop it from respiring and, in the long term, may lead to local cancers.  

Original Silica G5 supplementation on its own or in conjunction will help maintain the amount of collagen fibers and thereby delay skin ageing without having the disadvantages of the products mentioned above.   

CONCLUSION

Organic Silicon has multiple roles within the body as we have seen.  

Apart from its involvement in many biochemical reactions, we can consider that it is also a potentialiser for other metals and metalloids; it would appear that this is how silicon works as a co-factor in some enzyme reactions (Enzyme Metal Substrate).  

Its role in protecting glycan-proteins (proteins on the cell surface) should not be forgotten either.  

Original Silica G5 supplementation can be considered as a nano-nutrition supplement at several cellular levels that allows the body, through clearing out some stored aberrations, to be more receptive to other treatments. In this sense, we can consider a silicon supplement as having an impact on many pathological conditions.
Finally, the anti-free radicals’ effect of Original Silica G5 appears to be established and at the same time this confirms its broad anti-ageing effect on the body.